NeuroProtek (Original Formula) 60 Softgels by Algonot

NeuroProtek® is a unique all natural oral dietary supplement in a soft gel capsule, which may reduce symptoms of gut and brain inflammation and nerve damage. NeuroProtek® uses an exclusive combination of flavonoids, based on the scientific research of Dr. Theoharides M.D., PhD, which have shown to reduce oxidative stress and inflammation both in the gut and the brain. NeuroProtek® is formulated to maximize the anti-inflammatory affects of flavonoids while also overcoming any absorption obstacles. NeuroProtek® contains the flavonoids: Luteolin, Quercetin, and Rutin. Unique to Algonots formulations is olive kernel oil, a powerful anti-oxidant that is instrumental in helping the body absorb and delivery the dry flavonoids found in each soft gel capsule. NeuroProtek® is free of the following allergens: artificial colors or dyes, flavors or sweeteners, corn, eggs, fish, heavy metals, milk/casein, peanuts, preservatives, salt, shellfish, starch, sugar, tree nuts, wheat/gluten and yeast. Our ingredients are not obtained from beef or beef by-products.

Flavonoids are natural molecules found mostly in green plants and seeds. Unfortunately, our modern life diet contains progressively fewer flavonoids and those that are consumed are difficult to absorb because they do not dissolve in water. Under these conditions, the average person cannot consume enough to make a positive health difference. There are approximately 3,000 flavonoids. Of those, NeuroProtek® contains three:

Luteolin (Chamomile > 95% Pure) is one of the three flavonoids found in NeuroProtek® . Luteolin was incorporated in this formula after published papers showed it is important in the body: as a free radical scavenger, an agent in the prevention of inflammation, an immune system modulator and it mimics a normal compound that protects nerve damage.

Quercetin (Saphora Plant > 95% Pure) is a natural non-acidic (flavanoid) with potent anti-inflammatory capabilities. Quercetin is added to NeuroProtek® to help relieve the swelling associated from inflammatory disease and protect from further damage associated with mast cell activation. The Quercetin used in NeuroProtek® is obtained from the saphora plant. Algonot decisively choose not to use the more common and less expensive source of fava beans, which could cause hemolytic anemia, particularly in people of Mediterranean origin.

Rutin (Saphora Plant > 95% Pure) is a glycoside of the flavonoid Quercetin. Like quercetin, rutin is extracted from the saphora plant and is a non-acidic natural flavonoid that adds additional anti-inflammatory qualities. Rutin helps liberate quercetin in the intestine, making absorption easier. Rutin has been shown to be the strongest antioxidant in studies.

Olive Kernel Oil (Unprocessed, MicroFiltered) Olive kernel oil is a potent low-acidic anti-oxidant that can help repair damaged tissues. This unique oil (a lipid) plays an important role in NeuroProtek® as it is used to increase the absorbability of these flavonoids. We use only virgin olive seed oil from the island of Crete.

While some benefit may be noticed shortly after starting NeuroProtek, it may take 6-12 months before measurable benefits are observed . NeuroProtek® does not require a prescription. NeuroProtek is not a cure. NeuroProtek is not an analgesic.

People considering using NeuroProtek should consult their doctor. Please print this information or request a packet of information to be sent to your doctor.

Trademarks and Patents Dr. Theoharides developed NeuroProtek® and is the recipient of US patents No. 6,624,148; 6,689,748; 6,984,667; 7,115,278 and EPO 1365777, which cover methods and compositions of mast cell blockers in neuroinflammatory conditions. All patents have been assigned to Theta Biomedical Consulting and Development Co., Inc. (Brookline, MA, USA) The name NeuroProtek® has been trademarked in the USA with US registration No. 3225924 and has also been assigned to Theta Biomedical Consulting and Development Co., Inc. (Brookline, MA, USA) Potential Conflict Dr. Theoharides is the Scientific Director of Algonot, LLC but receives no compensation. All clinical trials with this product are being conducted or will be conducted under the supervision of other clinicians at sites other that the Academic Medical Center where Dr. Theoharides works.

Why the chosen flavonoids?
Flavonoids are naturally occurring compounds frequently found in green plants and seeds. In powder form, whether taken as pills, tablets or hard capsules, all flavonoids are difficult to absorb and are extensively metabolized to inactive ingredients in the liver. In fact, less than 10% of orally ingested flavonoids are absorbed.
In addition, very few flavonoids are beneficial; instead, many others such as morin have no anti- inflammatory activity, while pycnogenol is weakly active (as compared to luteolin or quercetin) but could cause liver toxicity.
As an additional consideration, the most common commercial source of the flavonoid quercetin is fava beans, which can induce hemolytic anemia (destruction of all the blood cells) in those of Mediterranean origin (15%), who lack the enzyme glucose-phosphate dehydrogenase (G6PD). Quercetin and its closely, structurally related flavonoids rutin and luteolin, have potent anti-oxidant and anti- inflammatory actions. Quercetin and luteolin can also inhibit the release of histamine and prostaglandin D2 (PGD2), as well as the pro-inflammatory molecules IL-6, IL-8, and TNF from human cultured mast cells. Moreover, quercetin inhibits mast cell activation stimulated by IL-1, and mast cell-dependent stimulation of activated T cells involved in auto- immune diseases. Luteolin also inhibits IL-6 release from microglia cells, as well as IL-1- mediated release of IL-6 and IL-8 from astrocytes. Quercetin also inhibited and reversed acute stress-induced autistic-like behavior and the associated reduced brain glutathione levels in mice. Can other preparations of the elect flavonoids be used?
There are about 3,000 flavonoids in nature and many impure flavonoids are sold under such names as
bioflavonoids, citrus flavonoids, soy flavonoids, or pycnogenol. Even those preparations claiming to
have only the select flavonoids, DO NOT specify either the source or the purity of the flavonoids. This problem is even worse given that many autistic patients could have reactions to the impurities, fillers or dyes.
The selection of specific beneficial flavonoids, as well as the source, purity and absorbability of those
flavonoids were taken into consideration in order to develop the most beneficial product with the least amount
of associated risk, NeuroProtek®.
References
Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000 Dec;52(4):673-751.
Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N, Cetrulo CL, Theoharides TC. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol. 2005 Aug;145(7):934-44.
Kandere-Grzybowska K, Kempuraj D, Cao J, Cetrulo CL, Theoharides TC. Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin. Br J Pharmacol. 2006
May;148(2):208-15.
Kempuraj D, Tagen M, Iliopoulou BP, Clemons A, Vasiadi M, Boucher W, House M, Wolfberg A, Theoharides TC. Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell- dependent stimulation of Jurkat T cells. Br J Pharmacol. 2008 Dec;155(7):1076-84.
Success Rate
Though to date the trials of NeuroProtek® are limited, the results are very promising. In the initial trial ten children (ages 3-8) diagnosed with autism were orally administered a total of four NeuroProtek® capsules per day for a period of 4 6 months. At the end of the trial period, the parents of the patients observed a significant improvement of core autism symptoms, such as poor communication skills and social interactions. In the best case outcome, two children (one boy and one girl, ages 4 and six years old, respectively), who prior to treatment were unable to speak, could not identify words, would get upset when asked to repeat a task, and would break into wing flapping movements, after treatment were able to answer simple questions, could make words with block letters, and would allow the researcher to hold them. Given the encouraging outcome of trials to date, applications for randomized, double-blind, placebo-controlled clinical trials have been submitted by Dr. Theoharides to the National Institute of Health, and the Department of Defense. Luteolin and Quercetin, and its related flavonoid rutin are safe because they are purified from chamomile. .
Riks/Side Effects
The NeuroProtek® formulation will be covered by a Certificate of Free Sale from the Food and Drug Administration (FDA). This certification ensures the amount, purity, source and manufacturing of the ingredients are in a facility inspected by the FDA and fulfilling Good Manufacturing Practices (GMP). There are no side effects known; however, this formulation (as well as any flavonoids) must be used with
caution with drugs that are heavily metabolized by the liver as it may affect the resulting blood levels of such compounds. References
Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol. 2007 Nov;45(11):2179-205.

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FDA. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

FAQ's

Common Questions

• Orders for products that are in stock are dispatched daily Monday – Friday.
• Orders placed before 3pm (CET) Monday – Friday will be dispatched the same day.
• Orders placed after 3pm (CET) Monday – Friday will be dispatched the next working day.
• As such, orders placed after 3pm (CET) on Friday will be dispatched the following Monday.
• Orders will not be dispatched on Bank Holidays (Netherlands) or Weekends.

Delivery

We have access to a variety of shipping options, provided by Deutsche Post, DPD and DHL Courier. You will select your delivery preference at the checkout when you place the order. We will endeavour to use your preferred delivery service wherever possible, while reserving the right to use an alternative courier of our choice as we deem necessary, this would always be a delivery upgrade, and never a downgrade.

As standard, we are only using delivery services that include tracking and insurance against damage/loss. This means if your parcel doesn’t arrive, or is damaged on arrival, you are entitled to a refund/replacement. All you need to do is send us some pictures of the damage. If you prefer to use a cheaper delivery service without tracking and insurance we can provide this for you by request, but if the parcel doesn’t arrive, or is damaged on arrival then you are not entitled to any refund/replacement/compensation.

Unless the delivery method you select contains the word ‘Guaranteed’, the delivery service is not guaranteed. For example – ‘Next-Day Delivery with DPD Courier’ is not guaranteed next-day delivery, and no compensation or refund is provided if the delivery guideline from the carrier is not met. If you select a guaranteed delivery service, and you do not receive the delivery within the delivery guideline after it has been dispatched, you are entitled to a full refund of the delivery cost.

The delivery guidelines for the services are below:

DHL Global Mail by Deutsche Post within Netherlands = 2-3 working days

DHL Global Mail by Deutsche Post within EU = 3-7 working days, depends on country

DPD Home Delivery within Netherlands = 1 working day

DPD Home Delivery within EU = 2-7 working days, depends on country.

DHL Express Courier within Netherlands = 1 working day, guaranteed.

DHL Express Courier within EU = 1-3 working days, depends on country.

We retain proof of postage at all times.

Shipping Issues, Delays, Lost Parcels etc.

At MandiMart we pride ourselves on our same-day dispatch and fast delivery. We are constantly on the lookout for ways to improve our delivery service and avoid delays for our customers.

It is your responsibility as the customer to ensure you have entered the correct shipping address. When you place an order, you will be sent a confirmation email confirming your order details. Your address and the product details are included in the order details; this is your opportunity to correct any possible mistakes with your order. If you become aware of errors with your order, please make us aware at the earliest possible time by sending an email to MandiMartLimited@gmail.com. We will endeavour to alter your order before it is dispatched. Unfortunately, if your order has already been packed and labelled at our warehouse, we cannot affect it in any way. We cannot be held responsible for any issues that arise due to the incorrect information you have provided.

While we try our absolute best to minimise any shipping errors, we are only human. In the event we have sent you the wrong product, we believe that we have caused enough inconvenience through our mistake, and as a result of this we will dispatch the correct product to you at the next available opportunity, irrespective of whether or not you have returned the incorrect product at that moment. However, we do ask that you return the incorrect product promptly, but at your leisure. Failure to return the incorrect products will incur an invoice and subsequently debt collection as required. 

If you have not received your order after the expected delivery guideline has passed, please contact your local post/delivery office, and quote your tracking number to them. In 90+% of cases a ‘failed delivery attempt’ has been made but the postman didn’t leave a card to let you know this. If the parcel is indeed at the local delivery office you will be able to re-arrange delivery or collection of your parcel via an online portal on the carrier’s website, or by contacting the local delivery office directly.

Unfortunately, we are not able to guarantee delivery or the time/date that our carrier will plan to make the delivery – this is out of our control. If you parcel is delayed or lost you can rest assured that we will do everything in our power to help you trace your lost parcel. This will include following up tracking numbers and contacting carriers for further clarification if the tracking information is not explicit. MandiMart cannot accept responsibility for delays or losses caused by carriers until the ‘claims waiting time’ has expired. Until this has happened the only message we will receive from carriers is to wait. After this time, we are more than happy to begin a complaint/claim against the carrier for the delay/loss of your parcel.

If you have entered a ‘SafePlace’ for your parcel to be left (i.e. when you are not present to accept the delivery) and the carrier states that they have left the parcel in the specified ‘SafePlace’, then MandiMart cannot be held responsible for any losses that you have experienced through using the ‘SafePlace’ service.

Returns

We understand that your supplement requirements are subject to change and, as such, you may occasionally need to return unused/no longer prescribed products. We offer a ‘no contest’ return policy if the product is in reasonable expiry date, in its original condition, unopened with the security seal still in place and the return is initiated within 90 days of the order being placed. If it has been longer than 90 days, send an email and we will decide this on a case-by-case basis.

We will process a refund once we have received the returned product, and inspected its condition. MandiMart accepts no responsibility for returns that are lost or damaged en route to our address. For this reason, we strongly recommend using a tracked/registered service and ensuring the products are adequately protected, as required.

MandiMart cannot accept opened, unsealed products for return in any situation other than a (possible) manufacturing defect. In this situation we require the product to be returned to us and then we will converse with our supplier/manufacturer as to whether a manufacturing defect is present in the product. This could include returning the product to our supplier/manufacturer. If a manufacturing defect is present then you will be issued a new product replacement or a refund, whichever you should prefer. Please note that the return shipping is to be paid by customer and only on discovery of a manufacturing defect will this be refunded. If there is no manufacturing defect present you will not be refunded nor will a replacement be sent to you.

While we continually strive for perfection, we are only human and mistakes will happen from time to time. If we have mistakenly sent you the wrong product, we are more than happy to cover the cost of returning this wrong product to us. We believe that you have been inconvenienced enough through no fault of your own, and as such should not have to pay for the return, or wait until the initial product is returned before the correct product is dispatched. We will immediately dispatch the correct product for you, with no regard to whether we have received your product return. However, in the instance that you have ordered the wrong product or no longer require the product you have ordered, we would expect you to fund the return yourself.

These conditions do not affect your statutory rights.