Vitamin B12 (Adenosylcobalamin)
One drop contains - Adenosylcobalamin (Vitamin B12) 75.9mcg.
Vitamin B12 Adenosylcobalamin 1.3 mg/ml in purified water
Humans need 13 different vitamins to sustain life and health. If we do not take in enough of a particular vitamin our bodily supplies decrease and a deficiency ensues.
Of the 13 vitamins our bodies need, one is B12. It is unique because it is the only vitamin that cannot be obtained from plants or sunlight (as plants do not need B12, so do not produce or store it), it is produced by bacteria in the gut of animals and absorbed in the small intestine. Therefore to obtain B12 from the diet you need to eat animal products - meat, fish or dairy products. However even a diet high in these foods may not supply enough B12. In fact it is remarkably easy to become deficient in B12 as many people can neither absorb nor use B12. Vegans and vegetarians are particularly prone to deficiency. The route that B12 takes from the mouth to the blood is complex and there can be problems at any point.
What does Vitamin B12 do?
- It contributes to the reduction of tiredness and fatigue
- It contributes to normal energy yielding metabolism
- It contributes to normal functioning of the nervous system
- It contributes to normal red blood cell formation
- It has a role in the process of cell division
- It contributes to normal homocysteine metabolism
- It contributes to normal psychological function
- It contributes to normal functioning of the immune system
The steps of the B12 pathway are:
- Food containing B12 is bound to animal proteins and needs to be freed. So when the food reaches the stomach it is split by an enzyme Pepsin (produced in the stomach only if sufficient amounts of Hydrochloric acid are present.)
- The stomach also produces Intrinsic Factor (IF), a protein that is needed later in the pathway.
- Other proteins known as R-Binders carry the B12 into the small intestine.
- In the intestine, Intrinsic Factor (from the stomach) attaches itself to the B12 and transports it to the last section of small intestine, the ileum. The cells lining the ileum contain receptors that grab onto the B12-Intrinsic Factor complex and drag it into the blood stream.
- In the bloodstream, another protein, transcobalamin2 carries the Vitamin B12 to all the cells in the body, transporting any extra to the liver for storage.
Adenosylcobalamin is also an "active" B12 form, making this coenzyme immediately available for use by the body. It is required for an enzyme known as MCM (Methylmalonyl Coenzyme A Mutase), which resides in the mitochondria and is needed to make succinyl CoA to produce energy in the citric acid cycle. In humans, Adenosylcobalamin is found mainly in the tissues especially the liver. It is the primary form of B12 found in non-human animals.
Deficiency of Vitamin B12
There is no one particular symptom that suggests a B12 deficiency. Symptoms may depend on the age and genetic disposition of the individual, and also the length and severity of deficiency. Because Vitamin B12 has so many functions, including the health of nerves, brain, blood and immune system, as well as the formation of DNA, B12 deficiency can impair functioning in almost any part of the body. The following signs and symptoms are common symptoms of B12 deficiency but can also arise from other causes.
Mental changes include irritability, apathy, sleepiness, paranoia, personality changes, depression, memory loss, dementia, hallucinations, violent behaviour and in children developmental delay and/or autistic behavior. Neurological signs and symptoms include pain, tingling or numbness, decreased sense of touch, pain or temperature, weakness, loss of awareness of body position, clumsiness, tremor, symptoms mimicking Parkinson’s disease or multiple sclerosis, spastic muscles, incontinence, paralysis, visual changes and damage to the optic nerve.
Vascular changes include, transient ischaemic attacks (TIAs or mini strokes), CVA or stroke, coronary artery disease, heart attack, congestive heart failure,
palpitations, low blood pressure when standing causing fainting, deep vein thrombosis (blood clot in the arm or leg) and pulmonary embolism.
Other signs and symptoms may include shortness of breath, generalised weakness, chronic fatigue or tiredness, loss of appetite and weight loss, epigastric pain (poor digestion, full or bloated feeling after eating normal or small meals), diarrhoea or constipation, increased susceptibility to infection, poor wound healing, failure of new born to thrive, tinnitus, vitiligo (white patches of skin), or hyperpigmentation, premature grey hair and impotence.
Anybody at any age can become deficient but people may be at an increased risk if they are:
- Vegans and vegetarians.
- Over 60.
- Have eating disorders such as anorexia or bulimia.
- Take antacids or diabetes related drugs that may interfere with B12 absorption.
- Have a history of alcoholism.
- Have a family history of pernicious anaemia.
- Are diagnosed with anaemia.
- Have Crohn’s disease, irritable bowel or any disease causing malaborption of nutrients.
- Have an autoimmune disease, type 1 diabetes, SLE, Addison’s disease.
- Women with a history of infertility or multiple miscarriages.
- Infants born to women or breast fed by women who are already deficient or at risk of B12 deficiency.
All forms of B12 are stable when protected from the light. Light exposure cleaves the cyanide with the production of hydroxycobalamin. The B12's have an optimal stability at a PH4.00-4.5, even at higher temperatures. In the presence of acid or alkaline mediator the presence of reducing agents such as ascorbic acid, the vitamin is destroyed to a greater extent. It is therefore advisable that B12 is not to be taken with fruit juice.
- Orders for products that are in stock are dispatched daily Monday – Friday.
- Orders placed before 3pm (CET) Monday – Friday will be dispatched the same day.
- Orders placed after 3pm (CET) Monday – Friday will be dispatched the next working day.
- As such, orders placed after 3pm (CET) on Friday will be dispatched the following Monday.
- Orders will not be dispatched on Bank Holidays (Netherlands) or Weekends.
We have access to a variety of shipping options, provided by Deutsche Post, DPD and DHL Courier. You will select your delivery preference at the checkout when you place the order. We will endeavour to use your preferred delivery service wherever possible, while reserving the right to use an alternative courier of our choice as we deem necessary, this would always be a delivery upgrade, and never a downgrade.
As standard, we are only using delivery services that include tracking and insurance against damage/loss. This means if your parcel doesn’t arrive, or is damaged on arrival, you are entitled to a refund/replacement. All you need to do is send us some pictures of the damage. If you prefer to use a cheaper delivery service without tracking and insurance we can provide this for you by request, but if the parcel doesn’t arrive, or is damaged on arrival then you are not entitled to any refund/replacement/compensation.
Unless the delivery method you select contains the word ‘Guaranteed’, the delivery service is not guaranteed. For example – ‘Next-Day Delivery with DPD Courier’ is not guaranteed next-day delivery, and no compensation or refund is provided if the delivery guideline from the carrier is not met. If you select a guaranteed delivery service, and you do not receive the delivery within the delivery guideline after it has been dispatched, you are entitled to a full refund of the delivery cost.
The delivery guidelines for the services are below:
DHL Global Mail by Deutsche Post within Netherlands = 2-3 working days
DHL Global Mail by Deutsche Post within EU = 3-7 working days, depends on country
DPD Home Delivery within Netherlands = 1 working day
DPD Home Delivery within EU = 2-7 working days, depends on country.
DHL Express Courier within Netherlands = 1 working day, guaranteed.
DHL Express Courier within EU = 1-3 working days, depends on country.
We retain proof of postage at all times.
Shipping Issues, Delays, Lost Parcels etc.
At MandiMart we pride ourselves on our same-day dispatch and fast delivery. We are constantly on the lookout for ways to improve our delivery service and avoid delays for our customers.
It is your responsibility as the customer to ensure you have entered the correct shipping address. When you place an order, you will be sent a confirmation email confirming your order details. Your address and the product details are included in the order details; this is your opportunity to correct any possible mistakes with your order. If you become aware of errors with your order, please make us aware at the earliest possible time by sending an email to MandiMartLimited@gmail.com. We will endeavour to alter your order before it is dispatched. Unfortunately, if your order has already been packed and labelled at our warehouse, we cannot affect it in any way. We cannot be held responsible for any issues that arise due to the incorrect information you have provided.
While we try our absolute best to minimise any shipping errors, we are only human. In the event we have sent you the wrong product, we believe that we have caused enough inconvenience through our mistake, and as a result of this we will dispatch the correct product to you at the next available opportunity, irrespective of whether or not you have returned the incorrect product at that moment. However, we do ask that you return the incorrect product promptly, but at your leisure. Failure to return the incorrect products will incur an invoice and subsequently debt collection as required.
If you have not received your order after the expected delivery guideline has passed, please contact your local post/delivery office, and quote your tracking number to them. In 90+% of cases a ‘failed delivery attempt’ has been made but the postman didn’t leave a card to let you know this. If the parcel is indeed at the local delivery office you will be able to re-arrange delivery or collection of your parcel via an online portal on the carrier’s website, or by contacting the local delivery office directly.
Unfortunately, we are not able to guarantee delivery or the time/date that our carrier will plan to make the delivery – this is out of our control. If you parcel is delayed or lost you can rest assured that we will do everything in our power to help you trace your lost parcel. This will include following up tracking numbers and contacting carriers for further clarification if the tracking information is not explicit. MandiMart cannot accept responsibility for delays or losses caused by carriers until the ‘claims waiting time’ has expired. Until this has happened the only message we will receive from carriers is to wait. After this time, we are more than happy to begin a complaint/claim against the carrier for the delay/loss of your parcel.
If you have entered a ‘SafePlace’ for your parcel to be left (i.e. when you are not present to accept the delivery) and the carrier states that they have left the parcel in the specified ‘SafePlace’, then MandiMart cannot be held responsible for any losses that you have experienced through using the ‘SafePlace’ service.
We understand that your supplement requirements are subject to change and, as such, you may occasionally need to return unused/no longer prescribed products. We offer a ‘no contest’ return policy if the product is in reasonable expiry date, in its original condition, unopened with the security seal still in place and the return is initiated within 90 days of the order being placed. If it has been longer than 90 days, send an email and we will decide this on a case-by-case basis.
We will process a refund once we have received the returned product, and inspected its condition. MandiMart accepts no responsibility for returns that are lost or damaged en route to our address. For this reason, we strongly recommend using a tracked/registered service and ensuring the products are adequately protected, as required.
MandiMart cannot accept opened, unsealed products for return in any situation other than a (possible) manufacturing defect. In this situation we require the product to be returned to us and then we will converse with our supplier/manufacturer as to whether a manufacturing defect is present in the product. This could include returning the product to our supplier/manufacturer. If a manufacturing defect is present then you will be issued a new product replacement or a refund, whichever you should prefer. Please note that the return shipping is to be paid by customer and only on discovery of a manufacturing defect will this be refunded. If there is no manufacturing defect present you will not be refunded nor will a replacement be sent to you.
While we continually strive for perfection, we are only human and mistakes will happen from time to time. If we have mistakenly sent you the wrong product, we are more than happy to cover the cost of returning this wrong product to us. We believe that you have been inconvenienced enough through no fault of your own, and as such should not have to pay for the return, or wait until the initial product is returned before the correct product is dispatched. We will immediately dispatch the correct product for you, with no regard to whether we have received your product return. However, in the instance that you have ordered the wrong product or no longer require the product you have ordered, we would expect you to fund the return yourself.
These conditions do not affect your statutory rights.